Former pupil Oscar Wilde won a scholarship to Trinity College Dublin, and his name appears on the school's Honours board.

There is also an Ulster History Circle Blue Plaque on the school building commemorating him.

Additionally, initials he had carved into the window casement of a classroom as a student there were removed.

[15] A proposal by the Department of Education to merge Portora Royal School with the Enniskillen Collegiate Grammar School to form Enniskillen Royal Grammar School was approved by the Minister of Education, John O'Dowd, in June 2015 but the matter was taken to the High Court in October 2015 due to much local opposition.

The High Court bid to stop the amalgamation of the two Enniskillen grammar schools failed.