The Portrait of Carlo de' Medici is a painting by the Italian Renaissance master Andrea Mantegna, executed in 1466.

This is however in contrast with the identification of Carlo as a character in Filippino Lippi's Stories of St. Stephen and St. John the Baptist in the Cathedral of Prato.

The painting shows the subject from a three-quarter view, an innovation brought in Italy through Flemish masters in the late 15th century; previously profiles, in the ancient Roman tradition, were preferred.

The subject is tan-skinned with intense blue eyes and wears the garments of a protonotary apostolic, a position which Carlo held from 1463.

The official nature of the painting explains the absence of any psychological element and the attention to details such as the dress and the hat.