Portrait of Diego Ortiz de Zúñiga is an oil on canvas portrait of the Spanish historian, writer and nobleman Diego Ortiz de Zúñiga, measuring 113 cm by 94 cm.

At that time it was thought to be an original Murillo, but (partly due to heavy discoloration in its varnish) it was reassigned as a copy by 1901.

[2] A copy of the work now hangs in the town hall in Seville, attributed to Domingo Martínez [es].

It once hung in the former Augustinian College of San Acacio in Seville, later converted into a town library.

The painting was finally donated to the city of Seville by the sitter's grandson José Ortiz de Zúñiga, marquis of Montefuerte.