The Portrait of Lady Shirley is a 1622 painting by Sir Anthony van Dyck, a Flemish Baroque artist.

It is a portrait of Teresa Sampsonia (1589–1668), a Circassian noblewoman of the Safavid Empire of Iran.

She was the wife of Elizabethan English adventurer Robert Shirley, whom she accompanied on his travels and embassies across Europe in the name of the Safavid King (Shah) Abbas the Great (r. 1588–1629).

[1] The painting is full-length portrait with the seated subject portrayed in a Circassian dress in dull gold, embroidered with blue and red, with a cinnamon mantle, typical of her homeland.

[3] These portraits are now owned by Petworth House, a National Trust property in West Sussex.