In 2013, the Palace became home to the Post Office Cultural Center of São Paulo, which offers free exhibitions and other artistic events.

Architects Domiziano Rossi and Felisberto Ranzini, from Ramos de Azevedo Technical Office, were responsible for the project.

[4] The Post Office Palace underwent an internal remodeling in the mid-1950s and between October 1978 and March 1979; in the latter, the renovation was also external, and aimed at cleaning the building, which was restored to its original condition.

[6] In 1997, the Correios held a national architectural competition, in which the competing firms had to draw up proposals for adapting the building's facilities into a cultural center.

[6] The first major restoration of the Post Office Palace began in 2005 as part of a City Hall initiative to revitalize the center of São Paulo.

The project, which cost R$10 million, aimed to maintain the building's original features and install a cultural center on the upper floors.

[7] The venue presents exhibitions on subjects such as humanities, music and visual arts, all in an accessible way, gathering in the same space both renowned and emerging artists, giving them the possibility of recognition and credibility.

[8][7] Some of the exhibitions the cultural center has hosted since its inauguration include: O Rio de Debret, with 120 watercolors by the French artist Jean-Baptiste Debret depicting life in the city of Rio de Janeiro in the period between the Colony and the Empire; the presentation by the artist Elifas Andreato, an important figure in the Brazilian popular music and theater scene, which brings together some of the main works produced by the artist over the course of his half-century career, in a trajectory linked to the golden age of Brazilian popular music, the fight against the military regime and the affirmation of Brazilian cultural identity; and the exhibition Sobrevoo by multimedia artist Marcos Amaro, featuring twenty large and medium-sized works made up of sculptures, three-dimensional collages and aeronautical waste materials.

[2][1][13] With the exception of some sections of the first floor, which were made of rough granite, the facade of the Post Office Palace is entirely covered in pigmented mortar.

Together with the Municipal Theater, the Martinelli Building and the Viaduto do Chá, it is part of an important architectural ensemble in the center of São Paulo.

The cultural center's agenda is diverse, promoting activities in the fields of visual arts, humanities and music, for all social groups and all ages, generally with free attractions.