Griffith, a Victorian botanist, and was named after him by the noted pondweed expert Arthur Bennett.

[2] In Llyn Anafon, Potamogeton x griffithii grows in clear, oligotrophic water with some basic influence, 0.75–3.2 m deep, among beds of Chara virgata[3] and in shallower water, in a more diverse community including Nitella opaca, N. translucens, Utricularia minor, Juncus bulbosus, Isoetes lacustris and Callitriche brutia var.

One of the parents, Potamogeton alpinus, grows in the inflow stream, but P. praelongus has never been recorded in or near the lake.

[1][3] Potamogeton × griffithii is classified as Vulnerable by both the British[4] and Welsh[5] Vascular Plant Red Lists due to the low number of sites in which it occurs.

A patch has been established in a wildlife pond in Bangor University's Treborth Botanic Garden, where it grows well on a sandy substrate in about 1 m depth.

In common with other pondweeds of this group it roots poorly from stem cuttings and is best propagated by division of the rhizomes.