In the late 1920s and early 1930s, Potez 25 was the standard multi-purpose aircraft of over 20 air forces, including French and Polish.

In May 1925, the prototype was tested at the Service Technique d'Aeronautique Institute and was found a promising construction both for its manoeuvrability, speed and durability.

It was bought by a number of air forces, including those of France, Switzerland, Belgium, Brazil, Croatia, Estonia, Ethiopia, Finland, Greece, Spain, Japan, Yugoslavia, Paraguay, Poland, Portugal, Romania, Turkey and the USSR.

After the USSR acquired two aircraft for testing, they decided against further purchases, finding it comparable to the native Polikarpov R-5.

In 1928 the first Polish-built Potez 25 were tested by the Technical Aviation Development Institute in Warsaw and the design was slightly modified to better fit the needs of the Polish air forces.

Altogether, 300 aircraft were built in a number of versions for long- and short-range reconnaissance and daylight tactical bombing.