[1] The game was well-received by critics, who commended its complex gameplay and its graphical style, but were disappointed at its lack of any voice acting.

Set in a fantasy universe, it revolves around a witch named Sylvia who inherits her uncle's potion shop, along with debt she must pay off.

[5] The soundtrack to Potionomics is written by Greg Nicolett and includes various collaborations with artists like Artemisia, Patti Rudisill, Joni Fuller, Tina Guo, Kristin Naigus, and Ro Rowan.

[1] Tom Sykes of PC Gamer rated it 87/100 points, particularly commending its card-based haggling battles as "light, brisk, yet packed with charm", but calling its potion-brewing "exhausting".

However, he expressed dislike of the game's lack of voice acting in comparison to its graphics, saying that he felt like he was "playing on mute".

[11] Potionomics: Masterwork Edition was also reviewed by Nintendo World Report, PSU, and Siliconera, who considered it superior to the original version.