He was born in Sardica (now Sofia, capital of Bulgaria) in the Roman province of Thracia (established in 107 after the Second Dacian War and later renamed Dacia Inferior).

His hagiography states that he came from a very rich pagan family and attributes many miracles to him, especially the curing of the madness of Antoninus Pius' daughter Agnes, which is described in a 9th-century Passio Sancti Potiti.

[1] His cult spread widely during the Middle Ages, reaching Capua, Naples and Benevento.

Ascoli Satriano has a church dedicated to him as well as a bust-reliquary containing part of his ulna in its former cathedral - this reliquary is carried round the town in procession between 18 and 20 August each year and at the end of the festival the ciuccio is burned.

Naples also once had a church dedicated to him, San Potito, served by Benedictines, whom pope Clement XII granted a special office in the saint's honour, with hymns edited by the Bollandists.