In every episode, the hosts discuss particular passages, themes, and questions from the Harry Potter books and films, and they go over the Potter-related news stories reported during the previous week by The Leaky Cauldron.

PotterCast frequently hosts contests, and it has presented a variety of themed shows, including a special wizard rock video edition and an episode for Banned Books Week 2005, in which staff interviewed representatives from the American Library Association.

It also covers breaking news, such as the press conference hosted by Warner Brothers before the release of Harry Potter and the Goblet of Fire.

PotterCast was launched on August 22, 2005, and with episode 130 it became the first podcast to interview Harry Potter author J.K. Rowling.

It has also inspired the creation of a few wizard rock bands, including Sue and the Hufflepuffs, Melissa and the Anellis, and MC Dawlish.