In 1899 the Queen Undermuslin Company was incorporated, and in 1904 it moved from a location on Mill Street into this building, forever leaving its mark on the property now known as the Poughkeepsie Underwear Factory.

The high quality of the product was confirmed by the Galveston Cotton Carnival and Exposition, where Queen Undermuslins took home top prize.

The company produced 60,000 garments annually, exclusively for women and children, and able to be procured "at any dry goods or furnishing house of any importance."

Employees (all women) were involved in resolving business disputes, and the grounds were lauded for their beautiful condition, included a perfectly manicured privet hedge, a large flower bed at the front of the site, and even a tennis court for recreation for the employees.

The redevelopment of the Poughkeepsie Underwear Factory is the anchor project in Hudson River Housing's work to revitalize the Middle Main Street corridor.