Pouilly-Fuissé (French pronunciation: [puji fɥise]) is an appellation (AOC) for white wine in the Mâconnais subregion of Burgundy in central France, located in the communes of Fuissé, Solutré-Pouilly, Vergisson and Chaintré.

Chardonnay is the only permitted grape here, and many of the wines produced are considered the same quality level as those made in the Côte de Beaune, without costing nearly as much.

West of Mâcon the land rises up to form Mont de Pouilly and other limestone hills, covered in the alkaline clay that best suits Chardonnay.

In a meeting with the poet Ernest Walsh, "at a restaurant that was the best and most expensive in the Boulevard St.-Michel quarter," the two dine on oysters "and a bottle of Pouilly Fuisse..." while discussing their mutual friends James Joyce and Ezra Pound.

In the Season 5, Episode 6 of The Mary Tyler Moore Show entitled "I Love a Piano", Murray returns to work intoxicated after having had a long lunch with a divorcee.

Jimmy Buffet's song "Landfall" contains a reference: "Oh, I love the smell of fresh snapper fried light; What'd you say, Pouilly-Fuisse could round out the night."

In Carl Hiaasen’s novel “Tourist Season” a coroner “found two gallstones, forty-seven grams of partially digested stone crabs, and thirteen ounces of Pouilly Fuisse” in the stomach of the character B.D.

Minx, Season 1, Episode 4, "An exciting new chapter in the annals of erotica", Joyce goes to retrieve a drink for herself and the fireman who asks for a beer.

In General Hospital Season 61 Episode 164 April 30th 2024 air date, Valentin and Anna are seen drinking a glass of Pouilly-Fuissé in the metro court.