Pouligny-Saint-Pierre (French pronunciation: [puliɲi sɛ̃ pjɛʁ] ⓘ) is a commune in the Indre department in central France.

The commune is known internationally for its goat's cheese, Pouligny-Saint-Pierre, that was first made in the village in the 19th century.

The commune is located in the parc naturel régional de la Brenne.

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