Pouxeux (French pronunciation: [puksø] ⓘ) is a commune in the Vosges department in Grand Est in northeastern France.

Pouxeux lies on the left bank of the Moselle, opposite its confluence with the little river Vologne.

Pouxeux station has rail connections to Épinal, Remiremont and Nancy.

Before the French Revolution, Pouxeux fell within the territory of Arches, under the bailiwick of Remiremont.

Under the administrative arrangements introduced in 1790 the commune was part of the canton of Éloyes.