The group has released eleven studio albums, gaining its highest level of commercial success with 1999's Tonight the Stars Revolt!, which reached number 29 on the Billboard 200 while spawning the singles "When Worlds Collide" and "Nobody's Real".

Frontman Spider One, younger brother of fellow metal musician Rob Zombie, has been the only consistent member of the lineup since the band's formation.

[8] Drummer Al Pahanish Jr., bassist Dorian Heartsong, guitarist Adam 12, and percussionist Jordan Cohen joined in 1991 to solidify the early lineup (a turntablist, Brian Collymoore, was also briefly a member until 1993).

In 1993, the band released an independent EP titled A Private Little War, which was limited to 500 copies and only sold at shows.

In 1994 and 1995, Powerman 5000 released two more independent records, the True Force EP and the full-length album The Blood-Splat Rating System.

In 1996, they performed on the second stage of Ozzfest and appeared in an episode of Beverly Hills, 90210, where David and Donna filmed a music video for their song "Strike the Match".

In 1996, the band signed to DreamWorks Records and released a remastered edition of The Blood-Splat Rating System titled Mega!!

Creating a strange fusion of science fiction and "Action Rock", Powerman 5000 released Tonight the Stars Revolt!, produced by Sylvia Massy, which contained the hit singles "When Worlds Collide", "Nobody's Real", and "Supernova Goes Pop".

Rapper Danny Boy guested, and the track was featured prominently during the end credits roll for the 2001 comedy film Zoolander, helping to widen the band's appeal.

In 2004, new music was released, under Spider's new label, in the form of a rarities album titled The Good, the Bad and the Ugly Vol.

The band then signed to DRT Entertainment, who released the album entitled Destroy What You Enjoy on August 1, 2006.

The band would go on to tour through the U.S., including a live appearance on G4tv's Attack of the Show!, where they performed the song "Return to the City of the Dead" from Destroy What You Enjoy.

Pino had just moved to Los Angeles and heard about the open slot through his friendship with Piggy D (bassist for Rob Zombie).

Finally, in December 2008, the new track "Super Villain" premiered on the band's Myspace page, showcasing their return to their platinum-selling sound of the late 1990s.

On January 28, 2009, a preview of tracks from their upcoming sixth studio album were posted on the group's Myspace page, containing clips from the songs "Super Villain", "V Is for Vampire", and "Horror Show".

[20] Released by Cleopatra Records, Copies, Clones & Replicants included covers of other new wave songs such as The Fixx's "One Thing Leads to Another" and Eddy Grant's "Electric Avenue".

[21] On July 11, 2012, Spider began teasing a new song by posting on his Twitter that "Someone sneaked a camera in the studio tonight and filmed the speaker while it blasted a new Powerman 5000 tune!".

[27] By October 21 that same year, the band released a short snippet of the track "Die on Your Feet" from the new album onto their official Facebook page.

[29] On June 4, 2018, the band announced they would be taking part of the "Summer of Screams" Tour in September, along with Mushroomhead and The Browning.

However, on August 23, it was announced the band had to cancel their performances for the tour for medical reasons involving Spider's vocals.

Kung Fu Radio featured a different style from the one which the band is generally known for; this album incorporated elements of heavy metal, hip hop, hard rock and funk.

RAW, Gran Turismo 3: A-Spec and WWE WrestleMania 21, along with the racing game Baja 1000; Score International.

Film soundtracks such as Dracula 2000, Evolution, Blade II, Freddy vs. Jason, Titan AE, Little Nicky, Zoolander and Bride of Chucky have all featured the work of Powerman 5000.