Próspero Penados del Barrio (August 28, 1925 – May 13, 2005) was a Guatemalan prelate of the Roman Catholic Church.

Born in Flores, Petén, Penados studied at the Seminario de Santiago in Guatemala and later at the Seminary of New Orleans, United States, to become a priest.

He was ordained priest on March 24, 1951, in Rome and continued to study at the Roman Gregorianum, obtaining a degree in theology.

On December 1, 1983, Penados was appointed as the XVII Metropolitan Archbishop of Guatemala City and prelate of Esquipulas by Pope John Paul II.

[4] Penados resigned from his archiepiscopal office in 2000, and was succeeded by Rodolfo Quezada Toruño as archbishop.