Průhonice is a municipality and village in Prague-West District in the Central Bohemian Region of the Czech Republic.

The first documented owners of the village are from the 1270s, when it was the property of a family that called itself the Lords of Průhonice.

Johann Nepomuk von Nostitz-Rieneck has completely rebuilt the Průhonice Castle in the Neoclassical style.

On 1 January 2023, the 5.2 km (3.2 mi) long section of the D1 motorway from Prague to Průhonice was reclassified to a first class road.

Later in 2010, it also has been included in the UNESCO list of World Heritage Sites (as part of Historic Centre of Prague).