In the late 1980s, Khan teamed up with Jade 4U (Nikkie van Lierop) and Olivier Adams to form Lords of Acid and multiple other projects including Channel X and Digital Orgasm.

In 1992, Channel X's "Rave the Rhythm" was included in the soundtrack for Basic Instinct, after director Paul Verhoeven had by chance heard the track in a New York City disco during the shooting.

At the end of 1999, Praga Khan performed as a solo act in the United States for the first time (as an opener for Lords of Acid, with the same musicians) and released the album Mutant Funk that same year.

In June 2010, Khan announced that the Lords of Acid project would be touring the US during July and August 2010, bringing along their friends My Life with the Thrill Kill Kult, for what was being billed as the "Sextreme Ball".

[6] Although the Lords of Acid had indicated that there was a dispute over the ownership of some of their "official" websites,[citation needed] Khan began using his personal and professional social media accounts, to help raise awareness of the tour.

Khan released the album SoulSplitter in 2013 and performed a concert at Ancienne Belgique (with support by Psy'Aviah) to celebrate 25 years on stage.