Although today it is only served by local trains and with limited passenger facilities, it is one of the largest stations in Prague by area, with 20 tracks and 6 platforms.

On the northern edge of the station yard, a small halt named Praha-Holešovice zastávka serves trains on track 091 from Prague to Kralupy nad Vltavou.

The station is not served directly by any trams or buses, but is 5 minutes walking distance from the tram system and 10 minutes from Vltavská metro station.

It is also located a short distance south from the more mainline Praha-Holešovice station.

In 2023, renovation work began on a section of the Prague–Kladno line including Praha–Bubny station.