Praha-Smíchov railway station (Czech: Nádraží Praha-Smíchov, [ˈsmiːxof]) is a major railway station in Prague, Czech Republic, located in Smíchov, in the south-west of the city.

[2] The station was opened in 1862 as the terminus of the line linking Prague to Plzeň, operated by Česká Západní Dráha (Czech Western Railway).

The present station building was built between 1953 and 1956 and designed by architects Jan Zázvorka and Ladislav Žák.

All trains going from Prague towards Plzeň and Písek pass through Smíchov as the first stop after the more central hub, Praha hlavní nádraží.

It is also used as a terminus for inter-regional trains serving cities in the east of the Czech Republic, which pass first through hlavní nádraží and terminate at Smíchov.