Prairie Bayou (March 4, 1990 – June 5, 1993) was an American Thoroughbred Champion racehorse owned and bred by Loblolly Stable of Lake Hamilton, Arkansas.
Named for a bayou between Little Rock and Hot Springs in Arkansas, he was sired by Little Missouri and out of the mare Whiffling.
Owned by Loblolly Stable, after Prairie Bayou's success on the racetrack, including the 1993 Preakness Stakes, Calumet Farm purchased Whiffling in foal to Danzig for $1,050,000 at the 1994 Keeneland November Sale.
In the final quarter, the gelding had to move to the far outside in order to make a strong stretch run that earned him a second-place finish behind Sea Hero.
Mike Smith, the jockey aboard Prairie Bayou, leaped off the horse as he broke down, and was unable as a result to pull him up and avoid further injury.