She was one of the organizers of the Department of Ethnography in Vilnius University in 1951 where she spent all her future scientific and educational activity.
Pranė Dundulienė published her first scientific paper in 1939, it was related to ethnographic relics and traditions of the Marcinkonys area in Lithuania.
Her two doctoral dissertations (1954 and 1969) were related to history of agriculture and farm implements in Lithuania.
Since 1948 each year she organized student expeditions to various regions of Lithuania to collect the relics of old household utensils, folk art objects, crochet works, national costumes, folklore (tales, songs, customs), astronomical knowledge (names of the planets, stars, constellations, etc.).
Mythology, religion and world outlook of the ancient Balts were permanent subjects of her scientific interests.