Following 1999, He was defeated by Marri Rajasekhar in 2004 Andhra Pradesh General Assembly Election.

Between 2014 and 2019, he served as Cabinet Minister and held various portfolios like Agriculture, Agri-Processing, Marketing and warehousing, Animal Husbandry, Dairy Development, Fisheries, Food & Civil Supplies, Price-Monitoring and Consumer Affairs.

In 2015, Prathipati Pulla Rao took part in the Telugu Desam Party's JanaChaitanya Yatra in Gudivada town of Krishna district.

In that year a total of 2,60,000 hectares of paddy crops were lost in the state due to heavy rains.

Nearly 6,000 hectares of fish and prawn cultures were damaged due to rains, therefore he asked the union government to sanction a large amount to Andhra Pradesh and help the farmers.