A number of foreign permanent missions are located in Pregny-Chambésy due to its proximity to most of Geneva's United Nations organizations and agencies as well as Geneva International Airport.

It went back to Savoy in 1567, was conquered by the Republic of Geneva in 1590, and then by France in 1601.

It finally joined the canton of Geneva in 1815 and thus the Swiss Confederacy.

[3] Pregny-Chambésy has an area, as of 2009[update], of 3.24 square kilometers (1.25 sq mi).

Of the rest of the land, 2.29 km2 (0.88 sq mi) or 70.7% is settled (buildings or roads), 0.03 km2 (7.4 acres) or 0.9% is either rivers or lakes.

while parks, green belts and sports fields made up 6.8%.

It originally consisted of the village of Pregny and the hamlets of Chambésy-Dessus and Chembésy-Dessous as well as the settlement of Roilbot.

[7] Most of the population (as of 2000[update]) speaks French (2,081 or 69.2%), with English being second most common (377 or 12.5%) and German being third (158 or 5.3%).

[7] The historical population is given in the following chart:[3][11] The Campagne Du Reposoir, the Rothschild Castle and outbuildings, the Museum des Suisses dans le monde, the Organisation mondiale de la santé (OMS) Archives and the Serres de Rothschild are listed as Swiss heritage site of national significance.

[12] In the 2009 Grand Conseil election, there were a total of 1,413 registered voters of which 640 (45.3%) voted.

The second most popular party was the Les Radicaux (with 14.5%), they were sixth in the canton-wide election, while the third most popular party was the Les Verts (with 13.1%), they were second in the canton-wide election.

[13] For the 2009 Conseil d'Etat election, there were a total of 1,410 registered voters of which 728 (51.6%) voted.

[13] In the 2011 federal election, the most popular party was the Les Libéraux-Radicaux which received 34.4% of the vote.

[7] There were 1,412 residents of the municipality who were employed in some capacity, of which females made up 45.7% of the workforce.

In the tertiary sector; 26 or 4.7% were in wholesale or retail sales or the repair of motor vehicles, 18 or 3.2% were in the movement and storage of goods, 65 or 11.7% were in a hotel or restaurant, 27 or 4.9% were in the information industry, 70 or 12.6% were the insurance or financial industry, 64 or 11.5% were technical professionals or scientists, 57 or 10.3% were in education and 136 or 24.5% were in health care.

[7] From the 2000 census[update], 945 or 31.4% were Roman Catholic, while 651 or 21.6% belonged to the Swiss Reformed Church.

The education system in the Canton of Geneva allows young children to attend two years of non-obligatory Kindergarten.

The canton's school system provides two years of non-mandatory kindergarten and requires students to attend six years of primary school, with some of the children attending smaller, specialized classes.

There were 70 lower secondary students who attended school in Pregny-Chambésy.