The quartiere is located in the eastern part of Rome, just behind the Aurelian Walls and Porta Maggiore.

To the north, the quarter borders with Quartiere Tiburtino (Q. VI), from which it is separated by the stretch of Via Prenestina between Piazzale Labicano and Largo Preneste, and with Quartiere Collatino (Q. XXII), the boundary being outlined by the stretch of Via Prenestina between Largo Preneste and Via Tor de' Schiavi.

Southward, the quarter borders with Quartiere Don Bosco (Q. XXIV), from which it is separated by the stretch of Via Casilina between Viale della Primavera and Via di Centocelle, as well as with Quartiere Tuscolano (Q. VIII), whose border is marked by the remaining portion of Via Casilina, up to Piazzale Labicano.

To the west, the quarter only shares a short border, crossing Piazzale Labicano, with Rione Esquilino (R. XV).

Besides the main roads, Via Prenestina and Via Casilina, and the streets and squares bearing a derivative name, such as Largo Preneste, Piazzale Prenestino, Via Labico, Piazzale Labicano and Vicolo Casilino, the odonyms of the quarter can be categorized as follows: gli odonimi del quartiere possono essere raggruppati nelle seguenti categorie: