In human anatomy, the presacral space is inside the pelvis, behind the rectum and in front of the coccyx and sacrum.

Others are retrorectal hamartoma (tailgut cyst), schwannoma, ganglioneuroma, and ependymoma.

Also sometimes found here is an anterior meningocele, a relatively mild form of neural tube defect.

Causes of increased pre-sacral space are: ulcerative colitis, granulomatous colitis, lymphogranuloma venereum, and in postirradiation changes, thrombosis of the inferior vena cava and tuberculous proctitis, tumor of the sacrum or posterior wall of the rectum.

Presacral edema is common in patients with heart failure who are confined to bed.