The oldest, continuously existing, established Christian Church in Ghana, it was started by the Basel missionaries on 18 December 1828.

In the 19th and early 20th centuries, the Presbyterian church had its missions concentrated in the southeastern parts of the Gold Coast and the peri-urban Akan hinterland.

In contemporary times, however, a 'praise and worship' segment, more commonly associated with evangelicalism, Pentecostalism and the charismatic movement, is sometimes incorporated into church services to meet the preferences of younger congregants.

[10] The Presbyterian Hymn Book is used during services and is available in primarily English, Ga, Twi, Ewe and other Ghanaian languages and dialects.

[12][4][7] PCG Statistics – 2001 to 2013 [needs update] Education is an integral part of the church's responsibility to the communities it operates in.

[13][10] Together with Ghanaian Anglicans, Methodists and Roman Catholics - Christian denominations that also prioritize higher education, Presbyterians in Ghana were historically disproportionately represented in the upper ranks of government, industry, academia and the professional occupations.

The church is the third largest provider of healthcare in Ghana, in terms of number of health facilities across the country in cities and towns such as Agogo, Bawku, Dormaa-Ahenkro, Donkorkrom, Bolgatanga, Salaga, Tease, Konongo, Duayaw-Nkwanta, Garu, Sandema, etc.

These institutions provide a substantial portion of health services in the rural areas with a workforce of 1,977 and total hospital beds of 745.

Curative, preventive and promotive services are provided to clients by the facilities in their respective catchment areas.

To this end, the Church established six (6) Agricultural Service stations in the late sixties in the Northern, Upper East, Eastern and Greater Accra regions of Ghana to complement the efforts of Government at poverty eradication in rural communities of the country.

The Clerk of the General Assembly position (previously Synod Clerk) is the chief ecclesial (ecclesiastical) officer of the general assembly, equivalent to as the chief administrative officer or secretary-general or executive secretary of the national church organisation, responsible for daily operations or performance.