The Missouri Pacific Depot of Prescott, Arkansas, United States, is located at 300 West 1st Street North.

One section continues to be reserved for railroad storage, while the other, the former passenger ticketing and waiting area, has been adapted for use by the local chamber of commerce and as a local history museum.

Exhibits include area settlers, railroads, and military items from World War I, World War II, the American Legion, National Guard of the United States, 1941 U.S. Army maneuvers in Prescott.

The depot building was listed on the National Register of Historic Places in 1978.

This article about a property in Nevada County, Arkansas on the National Register of Historic Places is a stub.