This article lists the presidents of São Tomé and Príncipe, an island country in the Gulf of Guinea off the western equatorial coast of Central Africa, since the establishment of the office of president in 1975.

Manuel Pinto da Costa was the first person to hold the office, taking effect on 12 July 1975.

The incumbent is Carlos Vila Nova, having taken office on 2 October 2021.

As of 2021, there is a two-term limit for the president in the Constitution of São Tomé and Príncipe.

The first president for whom the term limits applied was Trovoada in 2001.