Preston-Gaylord Cobblestone Farmhouse is a historic home located at Sodus in Wayne County, New York.

The cobblestone dwelling was built in 1845–1846, and consists of a 1+1⁄2-story main block and 1+1⁄2-story rear wing.

Both sections are constructed of irregularly sized and variously colored field cobbles.

Also on the property is a contributing two-story cobblestone carriage house dated to 1845–1846.

The structure is among the approximately 170 surviving cobblestone buildings in Wayne County.