Callander hired London-based architect Robert Mitchell to design a replacement house, and the foundation stone was laid on 18 March 1791.

Alterations made to the house in the early 19th century included the reversal of the front and rear elevations, and further development of the grounds.

[7] The front facade of Preston Hall has been compared to an illustration in the 1728 Essay in the Defence of Ancient Architecture by Robert Morris, and was considered somewhat dated at the time of its construction.

[3] The rear is more neoclassical in style, comprising a large central block flanked by pavilions.

The pavilions may predate the main building, possibly being part of William Adam's scheme, albeit remodelled by Mitchell.

At the end of a tree-lined vista to the north of the house is the octagonal-plan Temple, originally intended as Alexander Callander's mausoleum.