Preston High School, located on the bank of the Grand River in Cambridge, Ontario, first opened in 1934.

In 2007, approximately 300 students entered grade 9 and the total enrolment was 1253, which is a below-average number compared to other schools in the Waterloo region.

In the 2012 season the Panther's Junior football won the WCSSA championship, defeating the Jacob Hespeler Hawks.

Preston won the WCSSAA Championship for Boys Hockey in 2015 beating the Grand River Renegades 2-1, capturing their first title since 1996.

Preston has also seen great success at the Sears Ontario Drama Festival, frequently moving onto the Regional showcase, and receiving awards of merit and excellence for their productions.

The music department offers many traditional big band instruments, with a new addition of acoustic guitars.

These groups compete in the Georgian Bay Regional MusicFest, and the Ontario Vocal Festival.