Completely distinct from POHS, acute ocular histoplasmosis may rarely occur in immunodeficiency.

[1][2] Despite its name, the "presumed" relationship of POHS to Histoplasma capsulatum is controversial and has been questioned by a number of medical professionals.

[medical citation needed] Fluorescein angiography is usually performed for diagnosis and follow-up of patients with POHS.

A vitreo-retinal specialist (an ophthalmologist specialized in treatment of retinal diseases) should be consulted for proper management of the case.

[citation needed] Presumed ocular histoplasmosis syndrome and age-related macular degeneration (AMD) have been successfully treated with laser, anti-vascular endothelial growth factors and photodynamic therapy.