He made his MLB debut at the age of 24 after spending a season in the minor leagues for the New York Giants organization.

[5] He was officially listed as standing 5 feet 11 inches (180 cm) and weighing 180 pounds (82 kg) when he played professionally.

[2] Pezzullo began his professional baseball career in 1934, when he played for the Richmond Colts, an affiliate of the New York Giants.

[8] On November 1 of that year, Pezzullo was traded as a part of a four-man deal that sent him, Blondy Ryan, Johnny Vergez, George Watkins, and cash to the Philadelphia Phillies in exchange for Dick Bartell.

[16] After the season, he was sold to the double-A Toronto Maple Leafs of the International League, where, under managers Tony Lazzeri and Jack Burns, Pezzullo won 11 games and lost 12.

[13] After retiring from baseball, Pezzullo moved to Dallas, Texas, where he married Betty (née Tolcyk)[3] and had one daughter, Patti Moore.