[4] The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21[5] throughout the Salt Lake City and outer region.

[7][8] The hospital serves the states of Utah, Nevada, Idaho, Montana, and Wyoming,[9] yielding an enormous geographic catchment area of approximately 400,000 square miles.

An LDS organization and building, named "Deseret Hospital", was first founded in 1882 in Salt Lake City, but it closed for financial reasons in 1900.

[14] In July 2020 Primary Children's Hospital rolled out a new service for parents and families of babies that were in the neonatal intensive care unit (NICU).

The service run by company, AngelEye is able to provide video 24/7 to parents and families when they can't be in the NICU with their child.

[16] The hospital has a 32-bed pediatric intensive care unit to treat critically ill infants, children, teens, and young adults[17] and a 50-bed AAP verified Level 4 neonatal intensive care unit to handle critically ill infants.

The House was originally established in 1988 and has a capacity of 75 rooms for parents and families of infants, children, teens, and young adults aged 0–21 coming from over 60 miles outside of the area.

[23] In 2017, PCH was a semifinalist in the clinical care category of the Children's Hospital Association's annual Pediatric Quality Award.