He declined to attend the Fifth Ecumenical Council at Constantinople in the absence of the pope, and was the sole African to sign the papal constitutum to Emperor Justinian.
While at Constantinople, Primasius studied the exegesis of the Greeks, and his fame is chiefly due to his commentary on Revelation.
The work of Ticonius was considered by Primasius a piece of treasure adrift and belonging of right to the Church, needing only to be revised and expurgated.
Where Ticonius believed Revelation should be read in terms of the struggle of the Donatists with false brethren and gentiles, Primasius held the conflict properly lay between the Church and the world.
The first edition of Primasius's commentary was by Eucharius Cervicornus (Cologne, 1535; reprinted, Paris, 1544), but the most complete and still the most valuable is that of Basel, 1544, which is based on a very ancient manuscript of the Benedictine Monastery of Murbach in Upper Alsace.