This is a list of prime ministers of Mali since the country gained independence from France in 1960 to the present day.

A total of seventeen people have served as Prime Minister of Mali (not counting five acting prime ministers).

Additionally, one person, Modibo Keita, served on two non-consecutive occasions.

The current Interim Prime Minister of Mali is Abdoulaye Maïga, since 21 November 2024.

He was appointed by the National Committee for the Salvation of the People, which has governed the country since the 2021 Malian coup d'état.