This article lists the prime ministers of São Tomé and Príncipe, an island country in the Gulf of Guinea off the western equatorial coast of Central Africa, since the establishment of the office of prime minister of Portuguese São Tomé and Príncipe in 1974.

Leonel Mário d'Alva was the first person to hold the office, taking effect on 21 December 1974.

The incumbent is Américo Ramos, having taken office on 12 January 2025.