Primera División de México (Mexican First Division) Apertura 2005 was the 2005 edition of the Primera Division de Mexico, crowning Mexico's fall champion in football.
San Luis was promoted to the Primera División de México thus, Puebla was relegated to the Primera División A. Toluca won the championship and qualified for the CONCACAF Champions' Cup 2006.
Players sorted first by goals scored, then by last name.
Source: MedioTiempo Monterrey won 7–0 on aggregate.
Monterrey advanced for being the higher seeded team.