Primera División de México (Mexico First Division) Apertura 2006 was the 2006 edition of La Primera División del Futbol Méxicano, crowning Mexico's autumn football champion.
The season ran from August 5 to December 10, 2006.
Querétaro was promoted to the Primera División de México thus, Dorados was relegated to the Primera División A. Guadalajara won the championship for a record 11th time, qualifying for the CONCACAF Champions' Cup 2007.
Only regular season goals listed.
Source: MedioTiempo Toluca won 2–1 on aggregate.