It began on Friday, January 20, 2006, and ran until April 30, when the regular season ended.
On May 21, Pachuca defeated San Luis 1-0 and became champions for the fourth time.
Although the team fielded one of two top scorers for this season, Sebastian Abreu, Dorados de Sinaloa was relegated to Primera 'A' in a dramatic last game of regular season against San Luis.
Source: MedioTiempo Pachuca won 4–3 on aggregate.
Pachuca advanced for being the higher seeded team.