Primera División de México Invierno 2001 (Mexico First Division Winter 2001) is the second part of a two tournament season in Association football in Mexico.
La Piedad was promoted to Primera División de México, making possible that 19 teams took part in the Mexican First Division instead of the 18 teams in previous seasons.
Pachuca defeated UANL in the final, their second title win.
Pachuca advanced for being the higher seeded team.
UANL advanced for being the higher seeded team.