Route 12 is a 112 km (70 mi), two-lane, uncontrolled-access, secondary highway in western Prince Edward Island, Canada.

The route begins at its southern terminus, goes north, and turns left near Rosehill.

It continues north and turns left in Low Point.

Two left turns in Foxley River lead to a 2.7 km (1.7 mi) concurrency with Route 2 between Portage and West Devon.

Two bridges over the Trout and Mill rivers lead to a right turn into Alberton.