He was the first of five children: his younger brother Mahin (later King Mahinthrathirat) and three sisters Sawatdirat (who married Maha Thammaracha of Phitsanulok), Boromdilok and Thepkassatri.
[1]: 18–20 Prince Ramesuan and Maha Thammaracha was ordered to pursue the retreating forces, costing many Burmese lives.
This prompted Maha Chakkraphat to negotiate a peace with Tabinshwehti, which resulted in the turning over of two great war elephants and a cease fire.
After the war, the Prince was part of the party inside the Royal court that favoured the dismantling of the walls of the cities of Suphanburi, Lopburi and Nakhon Nayok, this was implemented as a way of depriving a future Burmese invasion with a fortified stronghold, only a day's march from the capital.
After holding out for many months the city of Phitsanulok surrendered to the Burmese forces, and Prince Ramesuan's brother-in-law, Maha Thammaracha decided to swear his allegiance to Bayinnaung.
The inhabitants of the city fearful of the noise and exhausted by the war, petitioned the king to surrender to the enemy and end their suffering.
As part of the peace settlement, the prince along with his father the fallen king and thousands of people were taken to Pegu in Burma on 28 March 1564, arriving there on 15 May 1564.