Prince of Wales Drive is the continuation of Queen Elizabeth Driveway beyond Preston Street.
It runs around Dow's Lake and through the Central Experimental Farm before reaching a roundabout.
There is a major intersection with Hunt Club Road, where several commuters from south Nepean use the bridge to cross the Rideau River.
Prince of Wales Drive follows the Rideau River past Barrhaven and Manotick.
Prior to the construction of Highway 416, the stretch of Highway 16 that included Prince of Wales continued south to the Canada–US border into Saint Lawrence County, New York In May 2007, the City approved the start of an environmental assessment study in regards of the future widening of the road from Fisher Avenue to Woodroffe Avenue from two to four lanes in accommodation to future expansion in Barrhaven, Manotick and Riverside South.