Françoise d'Orléans was born in Paris, the second daughter of Jean d'Orléans, duc de Guise (an Orléanist pretender to the throne of France under the name Jean III) and his wife, the French Princess Isabelle of Orléans.

[1] This was Christopher's second marriage - he was the youngest son of King George I of Greece (1845–1913) and his wife, Grand Duchess Olga Constantinovna of Russia (1851–1926).

[1] Through his father, he was thus a grandson of King Christian IX of Denmark (1818–1906), nicknamed "the father-in-law of Europe" due to his six children all marrying into other royal families.

[2] They had only one child, the writer Prince Michael of Greece and Denmark (1939-2024), whose marriage to the Greek artist Marina Karella (born 1940) did not conform to the laws of the royal house and thus deprived him of all right of succession to the Greek throne.

Her other grand-daughter is Princess Olga of Greece, who married Prince Aimone of Savoiy-Aosta, one of two claimants to be Head of the House of Savoy.