Princess Frederica of Prussia (30 September 1796 – 1 January 1850) was a daughter of Prince Louis Charles of Prussia and Frederica of Mecklenburg-Strelitz.

Her father was a younger son of Frederick William II of Prussia.

Due to her mother's later marriages, Frederica would have many half-siblings, including George V of Hanover.

On 18 April 1818, Frederica married Leopold IV, Duke of Anhalt-Dessau in Berlin.

This dynastic connection was an expression of Leopold's pro-Prussian policies.