She was the paternal grandmother of King Charles Albert of Sardinia, from whom the modern royal house of Italy descends.

Her brother, Charles Eugène de Lorraine, prince de Lambesc (25 September 1751 – 11 November 1825), escorted his kinswoman Marie Antoinette to France from Vienna in 1770, became Austrian ambassador to France, and would be the last male of the Guise branch of the House of Lorraine.

On 18 October 1768 Joséphine married Prince Victor Amadeus of Savoy, the son and heir of Louis Victor, Prince of Carignan and his German wife, the Landgravine Christine Henriette of Hesse-Rotenburg.

Amadeus was also the brother of the princesse de Lamballe,[1] the tragic confidante of Queen Marie Antoinette.

Prince Charles Emmanuel of Savoy was born to Joséphine in Turin on 24 October 1770.