Princess Louise was born on 30 January 1750 at Christiansborg Palace, the principal residence of the Danish Monarchy in central Copenhagen.

[2] The following year her father remarried to Duchess Juliana Maria of Brunswick-Wolfenbüttel, who gave birth to Louise's half-brother, Prince Frederick in 1753.

[1] After the removal and execution of Johann Friedrich Struensee on 28 April 1772 her husband found favour with the King again and with it, he was appointed commander-in-chief of the Norwegian army.

It was said that Charles planned to raise support in Norway for a coup to take the regency power over the king from prince Frederick and queen dowager Juliana.

They were very well received in Christiania, and upon their arrival in Trondhjem, one aristocrat, Nordahl Brun, welcomed them as the "heavenly couple", and greeted Louise with a poem.

[9] With her husband's larger income, he had Hermann von Motz build Louisenlund Castle on the land in Güby as a summer residence for the couple.

Her husband was also made Field Marshal the same year but would stay away from political circles and remain at Louisenlund till the 14th change of government in April 1784.