Although Princess Louise played a minor role in royal society, she helped establish the Luisestiftelsen—a charity organisation built for orphans—and pitched ideas for the construction of a residential home in Passow.

Her siblings included King Frederick William IV of Prussia, Kaiser Wilhelm I of Germany, Empress Charlotte of Russia (wife of Czar Nicholas I) and Alexandrine, Grand Duchess of Mecklenburg-Schwerin.

Since a young age, it was decided that Princess Louise would marry her first cousin, Prince Frederick of the Netherlands, who was her father's sister's son.

She is described as having had a strong closeness to her extended family, with whom she corresponded, and often visited her relatives and eventually also her children abroad, when they left the Netherlands after their marriages.

[1] Louise and her husband both contributed ideas for the construction of their residence in Passow, in collaboration with the architects Eduard Petzold and Jan David Zocher.